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An HMM-based algorithm for evaluating rates of receptor–ligand binding kinetics from thermal fluctuation data
Motivation: Abrupt reduction/resumption of thermal fluctuations of a force probe has been used to identify association/dissociation events of protein–ligand bonds. We show that off-rate of molecular dissociation can be estimated by the analysis of the bond lifetime, while the on-rate of molecular as...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3673216/ https://ncbi.nlm.nih.gov/pubmed/23599504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btt180 |
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