Investigating the Kinetic Mechanism of Inhibition of Elongation Factor 2 Kinase (eEF-2K) by NH125: Evidence for a Common in vitro Artifact

Evidence is emerging that elongation factor 2 kinase (eEF-2K) has potential as a target for anti-cancer therapy and possibly for the treatment of depression. Here the steady-state kinetic mechanism of eEF-2K is presented using a peptide substrate and is shown to conform to an ordered sequential mech...

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Main Authors: Devkota, Ashwini K., Tavares, Clint D. J., Warthaka, Mangalika, Abramczyk, Olga, Marshall, Kyle D., Kaoud, Tamer S., Gorgulu, Kivanc, Ozpolat, Bulent, Dalby, Kevin N.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3673019/
https://ncbi.nlm.nih.gov/pubmed/22352903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201787p
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