Reversible Covalent Inhibition of eEF-2K by Carbonitriles

eEF-2K is a potential target for treating cancer. However, potent specific inhibitors for this enzyme are lacking. Previously, we identified 2,6-diamino-4-(2-fluorophenyl)-4H-thiopyran-3,5-dicarbonitrile (DFTD) as an inhibitor of eEF-2K. In this paper, we describe its mechanism of action against eEF...

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Publicat a:Chembiochem
Autors principals: Devkota, Ashwini K., Edupuganti, Ramakrishna, Yan, Chunli, Shi, Yue, Jose, Jiney, Wang, Qiantao, Kaoud, Tamer S., Cho, Eun Jeong, Ren, Pengyu, Dalby, Kevin N.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482285/
https://ncbi.nlm.nih.gov/pubmed/25224652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402321
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