MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling

Inhibitors of the ALK and EGF receptor tyrosine kinases provoke dramatic but short-lived responses in lung cancers harboring EML4-ALK translocations or activating mutations of EGFR, respectively. We used a large-scale RNAi screen to identify MED12, a component of the transcriptional MEDIATOR complex...

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Autori principali: Huang, Sidong, Hölzel, Michael, Knijnenburg, Theo, Schlicker, Andreas, Roepman, Paul, McDermott, Ultan, Garnett, Mathew, Grernrum, Wipawadee, Sun, Chong, Prahallad, Anirudh, Groenendijk, Floris H., Mittempergher, Lorenza, Nijkamp, Wouter, Neefjes, Jacques, Salazar, Ramon, Dijke, Peter ten, Uramoto, Hidetaka, Tanaka, Fumihiro, Beijersbergen, Roderick L., Wessels, Lodewyk F.A., Bernards, René
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672971/
https://ncbi.nlm.nih.gov/pubmed/23178117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.10.035
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