Membrane Modulates Affinity for Calcium Ion to Create an Apparent Cooperative Binding Response by Annexin a5

Isothermal titration calorimetry was used to characterize the binding of calcium ion (Ca(2+)) and phospholipid to the peripheral membrane-binding protein annexin a5. The phospholipid was a binary mixture of a neutral and an acidic phospholipid, specifically phosphatidylcholine and phosphatidylserine...

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Main Authors: Gauer, Jacob W., Knutson, Kristofer J., Jaworski, Samantha R., Rice, Anne M., Rannikko, Anika M., Lentz, Barry R., Hinderliter, Anne
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2013
Fag:
Membrane
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672869/
https://ncbi.nlm.nih.gov/pubmed/23746516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.03.060
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