Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response

INTRODUCTION: The hypoxia-inducible factor (HIF)-1 pathway can stimulate tumor cell migration and metastasis. Furthermore, hypoxic tumors are associated with a poor prognosis. Besides the HIF-1 pathway, the unfolded protein response (UPR) is also induced by hypoxic conditions. The PKR-like ER kinase...

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Autores principales: Nagelkerke, Anika, Bussink, Johan, Mujcic, Hilda, Wouters, Bradly G, Lehmann, Steffi, Sweep, Fred CGJ, Span, Paul N
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672809/
https://ncbi.nlm.nih.gov/pubmed/23294542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3373
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