Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

INTRODUCTION: Early degeneration of the intervertebral disc (IVD) involves a change in cellular differentiation from notochordal cells (NCs) in the nucleus pulposus (NP) to chondrocyte-like cells (CLCs). The purpose of this study was to investigate the gene expression profiles involved in this proce...

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Detalhes bibliográficos
Main Authors: Smolders, Lucas A, Meij, Björn P, Onis, David, Riemers, Frank M, Bergknut, Niklas, Wubbolts, Richard, Grinwis, Guy CM, Houweling, Martin, Groot Koerkamp, Marian JA, van Leenen, Dik, Holstege, Frank CP, Hazewinkel, Herman AW, Creemers, Laura B, Penning, Louis C, Tryfonidou, Marianna A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672710/
https://ncbi.nlm.nih.gov/pubmed/23360510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4157
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