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Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

INTRODUCTION: Early degeneration of the intervertebral disc (IVD) involves a change in cellular differentiation from notochordal cells (NCs) in the nucleus pulposus (NP) to chondrocyte-like cells (CLCs). The purpose of this study was to investigate the gene expression profiles involved in this proce...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Smolders, Lucas A, Meij, Björn P, Onis, David, Riemers, Frank M, Bergknut, Niklas, Wubbolts, Richard, Grinwis, Guy CM, Houweling, Martin, Groot Koerkamp, Marian JA, van Leenen, Dik, Holstege, Frank CP, Hazewinkel, Herman AW, Creemers, Laura B, Penning, Louis C, Tryfonidou, Marianna A
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	BioMed Central 2013
الموضوعات:	Research Article
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3672710/ https://ncbi.nlm.nih.gov/pubmed/23360510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4157
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Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

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