LRRTM3 Interacts with APP and BACE1 and Has Variants Associating with Late-Onset Alzheimer’s Disease (LOAD)

Leucine rich repeat transmembrane protein 3 (LRRTM3) is member of a synaptic protein family. LRRTM3 is a nested gene within α-T catenin (CTNNA3) and resides at the linkage peak for late-onset Alzheimer’s disease (LOAD) risk and plasma amyloid β (Aβ) levels. In-vitro knock-down of LRRTM3 was previous...

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Autores principales: Lincoln, Sarah, Allen, Mariet, Cox, Claire L., Walker, Louise P., Malphrus, Kimberly, Qiu, Yushi, Nguyen, Thuy, Rowley, Christopher, Kouri, Naomi, Crook, Julia, Pankratz, V. Shane, Younkin, Samuel, Younkin, Linda, Carrasquillo, Minerva, Zou, Fanggeng, Abdul-Hay, Samer O., Springer, Wolfdieter, Sando, Sigrid B., Aasly, Jan O., Barcikowska, Maria, Wszolek, Zbigniew K., Lewis, Jada M., Dickson, Dennis, Graff-Radford, Neill R., Petersen, Ronald C., Eckman, Elizabeth, Younkin, Steven G., Ertekin-Taner, Nilüfer
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672107/
https://ncbi.nlm.nih.gov/pubmed/23750206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064164
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