The cannabinoid Δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity

BACKGROUND: Cannabinoid type-1 (CB1) receptor inverse agonists improve type 2 diabetes and dyslipidaemia but were discontinued due to adverse psychiatric effects. Δ(9)-Tetrahydrocannabivarin (THCV) is a neutral CB1 antagonist producing hypophagia and body weight reduction in lean mice. We investigat...

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Detalhes bibliográficos
Main Authors: Wargent, E T, Zaibi, M S, Silvestri, C, Hislop, D C, Stocker, C J, Stott, C G, Guy, G W, Duncan, M, Di Marzo, V, Cawthorne, M A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671751/
https://ncbi.nlm.nih.gov/pubmed/23712280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nutd.2013.9
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