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Synthesis of demissidine by a ring fragmentation 1,3-dipolar cycloaddition approach

[Image: see text] A synthesis of the steroidal alkaloid demissidine from epiandrosterone is reported. A ring fragmentation reaction that efficiently ruptured the D-ring of a diazo ester derivative of epiandrosterone to provide an aldehyde tethered ynoate product was key to this sequence. Incorporati...

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Hlavní autoři: Zhang, Zhe, Giampa, Geoffrey M., Draghici, Cristian, Huang, Qiufeng, Brewer, Matthias
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671602/
https://ncbi.nlm.nih.gov/pubmed/23586838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol4004993
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