Atherogenesis May Involve the Prooxidant and Proinflammatory Effects of Ferryl Hemoglobin

Oxidized cell-free hemoglobin (Hb), including covalently cross-linked Hb multimers, is present in advanced atherosclerotic lesions. Oxidation of Hb produces methemoglobin (Fe(3+)) and ferryl hemoglobin (Fe(4+) = O(2−)). Ferryl iron is unstable and can return to the Fe(3+) state by reacting with spec...

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Detalhes bibliográficos
Main Authors: Potor, László, Bányai, Emese, Becs, Gergely, Soares, Miguel P., Balla, György, Balla, József, Jeney, Viktória
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671302/
https://ncbi.nlm.nih.gov/pubmed/23766856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/676425
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