IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response

Endoplasmic reticulum (ER) stress activates a set of signaling pathways, collectively termed the unfolded protein response (UPR). The three UPR branches (IRE1, PERK, and ATF6) promote cell survival by reducing misfolded protein levels. UPR signaling also promotes apoptotic cell death if ER stress is...

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Detalhes bibliográficos
Main Authors: Lin, Jonathan H., Li, Han, Yasumura, Douglas, Cohen, Hannah R., Zhang, Chao, Panning, Barbara, Shokat, Kevan M., LaVail, Matthew M., Walter, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670588/
https://ncbi.nlm.nih.gov/pubmed/17991856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1146361
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