Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells

BACKGROUND: Current evidence indicates that a stem cell-like sub-population within malignant glioblastomas, that overexpress members of the adenosine triphosphate-binding cassette (ABC) family transporters, is responsible for multidrug resistance and tumour relapse. Eradication of the brain tumour s...

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Detalhes bibliográficos
Main Authors: Martín, V, Sanchez-Sanchez, A M, Herrera, F, Gomez-Manzano, C, Fueyo, J, Alvarez-Vega, M A, Antolín, I, Rodriguez, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670480/
https://ncbi.nlm.nih.gov/pubmed/23632480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.188
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