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Brief demethylation step allows the conversion of adult human skin fibroblasts into insulin-secreting cells

The differentiated state of mature cells of adult organisms is achieved and maintained through the epigenetic regulation of gene expression, which consists of several mechanisms including DNA methylation. The advent of induced pluripotent stem cell technology enabled the conversion of adult cells in...

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Bibliografske podrobnosti
Main Authors: Pennarossa, Georgia, Maffei, Sara, Campagnol, Marino, Tarantini, Letizia, Gandolfi, Fulvio, Brevini, Tiziana A. L.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670366/
https://ncbi.nlm.nih.gov/pubmed/23696663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220637110
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