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Brief demethylation step allows the conversion of adult human skin fibroblasts into insulin-secreting cells
The differentiated state of mature cells of adult organisms is achieved and maintained through the epigenetic regulation of gene expression, which consists of several mechanisms including DNA methylation. The advent of induced pluripotent stem cell technology enabled the conversion of adult cells in...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3670366/ https://ncbi.nlm.nih.gov/pubmed/23696663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220637110 |
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