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Brief demethylation step allows the conversion of adult human skin fibroblasts into insulin-secreting cells
The differentiated state of mature cells of adult organisms is achieved and maintained through the epigenetic regulation of gene expression, which consists of several mechanisms including DNA methylation. The advent of induced pluripotent stem cell technology enabled the conversion of adult cells in...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3670366/ https://ncbi.nlm.nih.gov/pubmed/23696663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220637110 |
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