Dependence of liver-specific transcription on tissue organization.

When the liver is disaggregated and hepatocytes are cultured as a cellular monolayer for 24 h, a sharp decline (80 to 99% decrease) in the transcription of most liver-specific mRNAs, but not common mRNAs, occurs (Clayton and Darnell, Mol. Cell. Biol. 2:1552-1561, 1983). A wide variety of culture con...

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Huvudupphovsmän: Clayton, D F, Harrelson, A L, Darnell, J E
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1985
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC366998/
https://ncbi.nlm.nih.gov/pubmed/3841792
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