Amplification of the gene for histidyl-tRNA synthetase in histidinol-resistant Chinese hamster ovary cells.

Histidinol-resistant (HisOHR) mutants with up to a 30-fold increase in histidyl-tRNA synthetase activity have been isolated by stepwise adaptation of wild-type Chinese hamster ovary (CHO) cells to increasing amounts of histidinol in the medium. Immunoprecipitation of [35S]methionine-labeled cell lys...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Tsui, F W, Andrulis, I L, Murialdo, H, Siminovitch, L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1985
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC366965/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2874482/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.5.9.2381-2388.1985
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