NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia

Despite improvements in treatment results for pediatric T-cell acute lymphoblastic leukemia, approximately 20% of patients relapse with dismal prognosis. PTEN inactivation and NOTCH1 activation are known frequent leukemogenic events but their effect on outcome is still controversial. We analyzed the...

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Bibliographic Details
Main Authors: Bandapalli, Obul R., Zimmermann, Martin, Kox, Corinne, Stanulla, Martin, Schrappe, Martin, Ludwig, Wolf-Dieter, Koehler, Rolf, Muckenthaler, Martina U., Kulozik, Andreas E.
Format: Artigo
Language:Inglês
Published: Ferrata Storti Foundation 2013
Subjects:
Original Articles and Brief Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3669450/
https://ncbi.nlm.nih.gov/pubmed/23349303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.073585
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