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Cancer Associated E17K Mutation Causes Rapid Conformational Drift in AKT1 Pleckstrin Homology (PH) Domain
BACKGROUND: AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is one of the most frequently activated proliferated and survival pathway of cancer. Recently it has been shown that E17K mutation in the Pleckstrin Homology (PH) domain of AKT1 protein leads to cancer by amplifying the phosph...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3669323/ https://ncbi.nlm.nih.gov/pubmed/23741320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064364 |
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