MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth

Some solid tumors have reduced posttranscriptional RNA editing by adenosine deaminase acting on RNA (ADAR) enzymes, but the functional significance of this alteration has been unclear. Here, we found the primary RNA-editing enzyme ADAR1 is frequently reduced in metastatic melanomas. In situ analysis...

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書誌詳細
主要な著者: Nemlich, Yael, Greenberg, Eyal, Ortenberg, Rona, Besser, Michal J., Barshack, Iris, Jacob-Hirsch, Jasmine, Jacoby, Elad, Eyal, Eran, Rivkin, Ludmila, Prieto, Victor G., Chakravarti, Nitin, Duncan, Lyn M., Kallenberg, David M., Galun, Eitan, Bennett, Dorothy C., Amariglio, Ninette, Bar-Eli, Menashe, Schachter, Jacob, Rechavi, Gideon, Markel, Gal
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2013
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668823/
https://ncbi.nlm.nih.gov/pubmed/23728176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI62980
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