Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis

The osteoblast-derived hormone osteocalcin promotes testosterone biosynthesis in the mouse testis by binding to GPRC6A in Leydig cells. Interestingly, Osteocalcin-deficient mice exhibit increased levels of luteinizing hormone (LH), a pituitary hormone that regulates sex steroid synthesis in the test...

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Main Authors: Oury, Franck, Ferron, Mathieu, Huizhen, Wang, Confavreux, Cyrille, Xu, Lin, Lacombe, Julie, Srinivas, Prashanth, Chamouni, Alexandre, Lugani, Francesca, Lejeune, Herve, Kumar, T. Rajendra, Plotton, Ingrid, Karsenty, Gerard
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2013
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Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668813/
https://ncbi.nlm.nih.gov/pubmed/23728177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65952
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