Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression

We designed class I/II hybrid inhibitory oligodeoxynucleotides (iODNs), called iSG, and found that the sequence 5′-TTAGGG-3′, which has a six-base loop head structure, and a 3′-oligo (dG)(3–5) tail sequence are important for potent immunosuppressive activity. Interestingly, splenocytes isolated from...

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Huvudupphovsmän: Ito, Yusuke, Shigemori, Suguru, Sato, Takashi, Shimazu, Tomoyuki, Hatano, Konomi, Otani, Hajime, Kitazawa, Haruki, Shimosato, Takeshi
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668506/
https://ncbi.nlm.nih.gov/pubmed/23847756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2012.11.002
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