DNA copy number profiling reveals extensive genomic loss in hereditary BRCA1 and BRCA2 ovarian carcinomas

BACKGROUND: Few studies have attempted to characterise genomic changes occurring in hereditary epithelial ovarian carcinomas (EOCs) and inconsistent results have been obtained. Given the relevance of DNA copy number alterations in ovarian oncogenesis and growing clinical implications of the BRCA-gen...

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Bibliografiska uppgifter
Huvudupphovsmän: Kamieniak, M M, Muñoz-Repeto, I, Rico, D, Osorio, A, Urioste, M, García-Donas, J, Hernando, S, Robles-Díaz, L, Ramón y Cajal, T, Cazorla, A, Sáez, R, García-Bueno, J M, Domingo, S, Borrego, S, Palacios, J, van de Wiel, M A, Ylstra, B, Benítez, J, García, M J
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2013
Ämnen:
Genetics and Genomics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668473/
https://ncbi.nlm.nih.gov/pubmed/23558894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.141
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