Van-Gogh-like 2 antagonises the canonical WNT pathway and is methylated in colorectal cancers

BACKGROUND: Aberrant activation of the canonical WNT signaling is a feature of colorectal cancer (CRC). Van-Gogh-like 2 (VANGL2) belongs to the non-canonical WNT pathway whose activation inhibits canonical WNT signaling. In this study, we investigated the role of VANGL2 and its epigenetic regulation...

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Detalhes bibliográficos
Main Authors: Piazzi, G, Selgrad, M, Garcia, M, Ceccarelli, C, Fini, L, Bianchi, P, Laghi, L, D'Angelo, L, Paterini, P, Malfertheiner, P, Chieco, P, Boland, C R, Bazzoli, F, Ricciardiello, L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668461/
https://ncbi.nlm.nih.gov/pubmed/23579212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.142
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