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Shab K(+) channel slow inactivation: A test for U-type inactivation and a hypothesis regarding K(+)-facilitated inactivation mechanisms

Herein, we report the first characterization of Shab slow inactivation. Open Shab channels inactivate within seconds, with two voltage-independent time constants. Additionally, Shab presents significant closed-state inactivation. We found that with short depolarizing pulses, shorter than the slowest...

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Detalhes bibliográficos
Main Authors: Carrillo, Elisa, Arias-Olguín, Imilla I., Islas, León D., Gómez-Lagunas, Froylan
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667890/
https://ncbi.nlm.nih.gov/pubmed/23419584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.23569
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