TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells

Mucin 5AC (MUC5AC) is secreted by goblet cells of the respiratory tract and, surprisingly, also expressed de novo in mucus secreting cancer lines. siRNA-mediated knockdown of 7343 human gene products in a human colonic cancer goblet cell line (HT29-18N2) revealed new proteins, including a Ca(2+)-act...

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Detalhes bibliográficos
Main Authors: Mitrovic, Sandra, Nogueira, Cristina, Cantero-Recasens, Gerard, Kiefer, Kerstin, Fernández-Fernández, José M, Popoff, Jean-François, Casano, Laetitia, Bard, Frederic A, Gomez, Raul, Valverde, Miguel A, Malhotra, Vivek
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667631/
https://ncbi.nlm.nih.gov/pubmed/23741618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00658
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