NIH/3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice.

NIH/3T3 cells transfected with DNA from malignant human tumors produced experimental and spontaneous metastases in nude mice. In contrast, parent or spontaneously transformed NIH/3T3 cells failed to metastasize. The transfected clones contained either activated c-Harvey-ras or N-ras oncogenes. A rep...

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Main Authors: Thorgeirsson, U P, Turpeenniemi-Hujanen, T, Williams, J E, Westin, E H, Heilman, C A, Talmadge, J E, Liotta, L A
Format: Artigo
Sprog:Inglês
Udgivet: 1985
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC366702/
https://ncbi.nlm.nih.gov/pubmed/3982418
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