Phosphorylation of the CENP-A amino-terminus in mitotic centromeric chromatin is required for kinetochore function

The role of the mitotic phosphorylation of the amino (NH(2)) terminus of Centromere Protein A (CENP-A), the histone variant epigenetic centromeric marker, remains elusive. Here, we show that the NH(2) terminus of human CENP-A is essential for mitotic progression and that localization of CENP-C, anot...

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Bibliographic Details
Main Authors: Goutte-Gattat, Damien, Shuaib, Muhammad, Ouararhni, Khalid, Gautier, Thierry, Skoufias, Dimitrios A., Hamiche, Ali, Dimitrov, Stefan
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666736/
https://ncbi.nlm.nih.gov/pubmed/23657009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302955110
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