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Structural plasticity of the cellular prion protein and implications in health and disease

Two lines of transgenic mice expressing mouse/elk and mouse/horse prion protein (PrP) hybrids, which both form a well-structured β2–α2 loop in the NMR structures at 20 °C termed rigid-loop cellular prion proteins (RL-PrP(C)), presented with accumulation of the aggregated scrapie form of PrP in brain...

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Detalhes bibliográficos
Principais autores: Christen, Barbara, Damberger, Fred F., Pérez, Daniel R., Hornemann, Simone, Wüthrich, Kurt
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666714/
https://ncbi.nlm.nih.gov/pubmed/23650394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1306178110
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