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An Automated System for Monitoring and Regulating the pH of Bicarbonate Buffers

The bicarbonate buffer is considered as the most biorelevant buffer system for the simulation of intestinal conditions. However, its use in dissolution testing of solid oral dosage forms is very limited. The reason for this is the thermodynamic instability of the solution containing hydrogen carbona...

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Hlavní autoři: Garbacz, Grzegorz, Kołodziej, Bartosz, Koziolek, Mirko, Weitschies, Werner, Klein, Sandra
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666009/
https://ncbi.nlm.nih.gov/pubmed/23468339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-013-9933-5
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