Development and Evaluation of Sustained-Release Etoposide-Loaded Poly(ε-Caprolactone) Implants

Poly(ε-caprolactone) implants containing etoposide, an important chemotherapeutic agent and topoisomerase II inhibitor, were fabricated by a melt method and characterized in terms of content uniformity, morphology, drug physical state, and sterility. In vitro and in vivo drug release from the implan...

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Autores principales: Solano, Ana Gabriela Reis, de Fátima Pereira, Adriana, Pinto, Flavia Carmo Horta, Ferreira, Letícia Gonçalves Resende, de Oliveira Barbosa, Leandro Augusto, Fialho, Silvia Ligório, de Oliveira Patricio, Patrícia Santiago, da Silva Cunha, Armando, da Silva, Gisele Rodrigues, Pianetti, Gérson Antônio
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer US 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666007/
https://ncbi.nlm.nih.gov/pubmed/23666789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-013-9977-6
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