CDC25A Protein Stability Represents a Previously Unrecognized Target of HER2 Signaling in Human Breast Cancer: Implication for a Potential Clinical Relevance in Trastuzumab Treatment

The CDC25A-CDK2 pathway has been proposed as critical for the oncogenic action of human epidermal growth factor receptor 2 (HER2) in mammary epithelial cells. In particular, transgenic expression of CDC25A cooperates with HER2 in promoting mammary tumors, whereas CDC25A hemizygous loss attenuates th...

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Detalhes bibliográficos
Main Authors: Brunetto, Emanuela, Ferrara, Anna Maria, Rampoldi, Francesca, Talarico, Anna, Cin, Elena Dal, Grassini, Greta, Spagnuolo, Lorenzo, Sassi, Isabella, Ferro, Antonella, Cuorvo, Lucia Veronica, Barbareschi, Mattia, Piccinin, Sara, Maestro, Roberta, Pecciarini, Lorenza, Doglioni, Claudio, Cangi, Maria Giulia
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665943/
https://ncbi.nlm.nih.gov/pubmed/23730206
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