CDC25A Protein Stability Represents a Previously Unrecognized Target of HER2 Signaling in Human Breast Cancer: Implication for a Potential Clinical Relevance in Trastuzumab Treatment

The CDC25A-CDK2 pathway has been proposed as critical for the oncogenic action of human epidermal growth factor receptor 2 (HER2) in mammary epithelial cells. In particular, transgenic expression of CDC25A cooperates with HER2 in promoting mammary tumors, whereas CDC25A hemizygous loss attenuates th...

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Autores principales: Brunetto, Emanuela, Ferrara, Anna Maria, Rampoldi, Francesca, Talarico, Anna, Cin, Elena Dal, Grassini, Greta, Spagnuolo, Lorenzo, Sassi, Isabella, Ferro, Antonella, Cuorvo, Lucia Veronica, Barbareschi, Mattia, Piccinin, Sara, Maestro, Roberta, Pecciarini, Lorenza, Doglioni, Claudio, Cangi, Maria Giulia
Formato: Artigo
Lenguaje:Inglês
Publicado: Neoplasia Press Inc. 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665943/
https://ncbi.nlm.nih.gov/pubmed/23730206
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