Conversion of Human Umbilical Cord Mesenchymal Stem Cells in Wharton’s Jelly to Dopamine Neurons Mediated by the Lmx1a and Neurturin In Vitro: Potential Therapeutic Application for Parkinson’s Disease in a Rhesus Monkey Model

hUC-MSCs hold great promise in vitro neuronal differentiation and therapy for neurodegenerative disorders including Parkinson’s disease. Recent studies provided that Lmx1α play an important role in the midbrain dopamine cells differentiation. Neurturin is desired candidate gene for providing a neuro...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yan, Min, Sun, Maosheng, Zhou, Yan, Wang, Wanpu, He, Zhanlong, Tang, Donghong, Lu, Shuaiyao, Wang, Xiaonan, Li, Song, Wang, Wenju, Li, Hongjun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665802/
https://ncbi.nlm.nih.gov/pubmed/23724014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064000
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