SYNTHESIS, ANTIDEPRESSANT EVALUATION AND DOCKING STUDIES OF LONG-CHAIN ALKYLNITROQUIPAZINES AS SEROTONIN TRANSPORTER INHIBITORS

Twelve alkyl analogues (1 - 12) of the high-affinity serotonin transporter (SERT) inhibitor 6-nitroquipazine (6-NQ) were synthesised and studied using in vitro radioligand competition binding assays to determine their binding affinity (K(i)). The putative antidepressant activity of five of the binde...

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Main Authors: Gabrielsen, Mari, Wołosewicz, Karol, Zawadzka, Anna, Kossakowski, Jerzy, Nowak, Gabriel, Wolak, Małgorzata, Stachowicz, Katarzyna, Siwek, Agata, Ravna, Aina W., Kufareva, Irina, Kozerski, Lech, Bednarek, Elżbieta, Sitkowski, Jerzy, Bocian, Wojciech, Abagyan, Ruben, Bojarski, Andrzej J., Sylte, Ingebrigt, Chilmonczyk, Zdzisław
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665732/
https://ncbi.nlm.nih.gov/pubmed/23574807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12116
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