Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia

BACKGROUND: It is a great challenge of modern biology to determine the functional roles of non-synonymous Single Nucleotide Polymorphisms (nsSNPs) on complex phenotypes. Statistical and machine learning techniques establish correlations between genotype and phenotype, but may fail to infer the biolo...

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Detalhes bibliográficos
Main Authors: Xie, Li, Ng, Clara, Ali, Thahmina, Valencia, Raoul, Ferreira, Barbara L, Xue, Vincent, Tanweer, Maliha, Zhou, Dan, Haddad, Gabriel G, Bourne, Philip E, Xie, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665574/
https://ncbi.nlm.nih.gov/pubmed/23819581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-14-S3-S9
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