RUNX3 gene promoter demethylation by 5-Aza-CdR induces apoptosis in breast cancer MCF-7 cell line

Runt-related transcription factor 3 (RUNX3) is a tumor suppressor gene, its inactivation due to hypermethylation related to carcinogenesis. The aim of this study was to investigate the effects of 5-aza-2′-deoxycytidine (5-Aza-CdR) on cell proliferation and apoptosis by demethylation of the promoter...

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Autores principales: Kang, Hua-Feng, Dai, Zhi-Jun, Bai, He-Ping, Lu, Wang-Feng, Ma, Xiao-Bin, Bao, Xing, Lin, Shuai, Wang, Xi-Jing
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665559/
https://ncbi.nlm.nih.gov/pubmed/23723708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S43744
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