Alpha-Particle Emitting (213)Bi-Anti-EGFR Immunoconjugates Eradicate Tumor Cells Independent of Oxygenation

Hypoxia is a central problem in tumor treatment because hypoxic cells are less sensitive to chemo- and radiotherapy than normoxic cells. Radioresistance of hypoxic tumor cells is due to reduced sensitivity towards low Linear Energy Transfer (LET) radiation. High LET α-emitters are thought to eradica...

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Detalhes bibliográficos
Main Authors: Wulbrand, Christian, Seidl, Christof, Gaertner, Florian C., Bruchertseifer, Frank, Morgenstern, Alfred, Essler, Markus, Senekowitsch-Schmidtke, Reingard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665541/
https://ncbi.nlm.nih.gov/pubmed/23724085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064730
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