α-Radioimmunotherapy with (213)Bi-anti-CD38 immunoconjugates is effective in a mouse model of human multiple myeloma

In spite of development of molecular therapeutics, multiple myeloma (MM) is fatal in most cases. CD38 is a promising target for selective treatment of MM. We tested radioimmunoconjugates consisting of the α-emitter (213)Bi coupled to an anti-CD38 MAb in preclinical treatment of MM. Efficacy of (213)...

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Publicat a:Oncotarget
Autors principals: Teiluf, Katharina, Seidl, Christof, Blechert, Birgit, Gaertner, Florian C., Gilbertz, Klaus-Peter, Fernandez, Vanesa, Bassermann, Florian, Endell, Jan, Boxhammer, Rainer, Leclair, Stephane, Vallon, Mario, Aichler, Michaela, Feuchtinger, Annette, Bruchertseifer, Frank, Morgenstern, Alfred, Essler, Markus
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467108/
https://ncbi.nlm.nih.gov/pubmed/25576914
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