Improvement of Cancer Immunotherapy by Combining Molecular Targeted Therapy

In human cancer cells, a constitutive activation of MAPK, STAT3, β-catenin, and various other signaling pathways triggers multiple immunosuppressive cascades. These cascades result in the production of immunosuppressive molecules (e.g., TGF-β, IL-10, IL-6, VEGF, and CCL2) and induction of immunosupp...

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Bibliographische Detailangaben
Hauptverfasser: Kawakami, Yutaka, Yaguchi, Tomonori, Sumimoto, Hidetoshi, Kudo-Saito, Chie, Iwata-Kajihara, Tomoko, Nakamura, Shoko, Tsujikawa, Takahiro, Park, Jeong Hoon, Popivanova, Boryana K., Miyazaki, Junichiro, Kawamura, Naoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2013
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664832/
https://ncbi.nlm.nih.gov/pubmed/23755373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00136
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