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The Yin and Yang of tRNA: proper binding of acceptor end determines the catalytic balance of editing and aminoacylation
Faithful translation of the genetic code depends on accurate coupling of amino acids with cognate transfer RNAs (tRNAs) catalyzed by aminoacyl-tRNA synthetases. The fidelity of leucyl-tRNA synthetase (LeuRS) depends mainly on proofreading at the pre- and post-transfer levels. During the catalytic cy...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3664829/ https://ncbi.nlm.nih.gov/pubmed/23585282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt252 |
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