Developing BACE-1 inhibitors for FXS

Fragile X syndrome (FXS) is a debilitating genetic disorder with no cure and few therapeutic options. Excessive signaling through metabotropic glutamate receptor 5 in FXS leads to increased translation of numerous synaptic proteins and exaggerated long-term depression. Two of the overexpressed prote...

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Autores principales: Westmark, Cara J., Berry-Kravis, Elizabeth M., Ikonomidou, Chrysanthy, Yin, Jerry C. P., Puglielli, Luigi
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664772/
https://ncbi.nlm.nih.gov/pubmed/23754978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2013.00077
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