Intratumor Hypoxia Promotes Immune Tolerance by Inducing Regulatory T Cells via TGF-β1 in Gastric Cancer

Regulatory T cell (Treg)-mediated immunosuppression represents one of the crucial tumor immune evasion mechanisms and is a main obstacle for successful tumor immunotherapy. Hypoxia, a common feature of solid tumors, has been associated with potentiated immunosuppression, decreased therapeutic respon...

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Bibliographische Detailangaben
Hauptverfasser: Deng, Bin, Zhu, Ji-Min, Wang, Yi, Liu, Tao-Tao, Ding, Yan-Bing, Xiao, Wei-Ming, Lu, Guo-Tao, Bo, Ping, Shen, Xi-Zhong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664556/
https://ncbi.nlm.nih.gov/pubmed/23723999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063777
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