Soluble Epoxide Hydrolase Gene Deficiency or Inhibition Attenuates Chronic Active Inflammatory bowel disease in IL-10(−/−) Mice

BACKGROUND: Soluble epoxide hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids (EETs) into their much less active dihydroxy derivatives dihydroxyeicosatrienoic acids (DHETs). Thus, targeting sEH would be important for inflammation. AIMS: To determine whether knockout or inhibiti...

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Main Authors: Zhang, Wanying, Yang, Allison L., Liao, Jie, Li, Haonan, Dong, Hua, Chung, Yeon Tae, Bai, Han, Matkowskyj, Kristina A., Hammock, Bruce D., Yang, Guang-Yu
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664520/
https://ncbi.nlm.nih.gov/pubmed/22588244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10620-012-2217-1
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