Genetic Variation Within a Metabolic Motif in the Chromogranin A Promoter: Pleiotropic Influence on Cardiometabolic Risk Traits in Twins

BACKGROUND: The cardiometabolic syndrome comprised of multiple correlated traits, but its origin is incompletely understood. Chromogranin A (CHGA) is required for formation of the catecholamine secretory pathway in sympathochromaffin cells. In twin pair studies, we found that CHGA traits aggregated...

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Bibliografiske detaljer
Main Authors: Rao, Fangwen, Chiron, Stephane, Wei, Zhiyun, Fung, Maple M., Chen, Yuqing, Wen, Gen, Khandrika, Srikrishna, Ziegler, Michael G., Benyamin, Beben, Montgomery, Grant, Whitfield, John B., Martin, Nicholas G., Waalen, Jill, Hamilton, Bruce A., Mahata, Sushil K., O’Connor, Daniel T.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664223/
https://ncbi.nlm.nih.gov/pubmed/21918574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ajh.2011.163
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