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Identification of Core DNA Elements that Target Somatic Hypermutation
Somatic hypermutation (SHM) diversifies the variable region of Ig genes and underlies the process of affinity maturation, in which B lymphocytes producing high affinity antibodies are generated and selected. SHM is triggered in activated B cells by deamination of deoxycytosine residues mediated by a...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3664039/ https://ncbi.nlm.nih.gov/pubmed/23087403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202082 |
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