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White matter hyperintensities and amyloid are independently associated with entorhinal cortex volume among individuals with mild cognitive impairment

BACKGROUND: Current hypothetical models of Alzheimer’s disease (AD) pathogenesis emphasize the role of beta amyloid, tau deposition, and neurodegenerative changes in the mesial temporal lobe, particularly entorhinal cortex and hippocampus. However, many individuals with clinical AD who come to autop...

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Bibliographic Details
Main Authors: Guzman, Vanessa A., Carmichael, Owen T., Schwarz, Christopher, Tosto, Giuseppe, Zimmerman, Molly E., Brickman, Adam M.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663926/
https://ncbi.nlm.nih.gov/pubmed/23375566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2012.11.009
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