Augmentation of Antitumor Immunity by Fusions of Ethanol-Treated Tumor Cells and Dendritic Cells Stimulated via Dual TLRs through TGF-β1 Blockade and IL-12p70 Production

The therapeutic efficacy of fusion cell (FC)-based cancer vaccine generated with whole tumor cells and dendritic cells (DCs) requires the improved immunogenicity of both cells. Treatment of whole tumor cells with ethanol resulted in blockade of immune-suppressive soluble factors such as transforming...

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Main Authors: Koido, Shigeo, Homma, Sadamu, Okamoto, Masato, Namiki, Yoshihisa, Takakura, Kazuki, Takahara, Akitaka, Odahara, Shunichi, Tsukinaga, Shintaro, Yukawa, Toyokazu, Mitobe, Jimi, Matsudaira, Hiroshi, Nagatsuma, Keisuke, Kajihara, Mikio, Uchiyama, Kan, Arihiro, Seiji, Imazu, Hiroo, Arakawa, Hiroshi, Kan, Shin, Hayashi, Kazumi, Komita, Hideo, Kamata, Yuko, Ito, Masaki, Hara, Eiichi, Ohkusa, Toshifumi, Gong, Jianlin, Tajiri, Hisao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663747/
https://ncbi.nlm.nih.gov/pubmed/23717436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063498
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