Alterations of the genes involved in the PI3K and estrogen-receptor pathways influence outcome in human epidermal growth factor receptor 2-positive and hormone receptor-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemotherapy

BACKGROUND: Chemotherapy with trastuzumab is widely used for patients with human epidermal growth factor receptor 2-positive (HER2+) breast cancer, but a significant number of patients with the tumor fail to respond, or relapse. The mechanisms of recurrence and biomarkers that indicate the response...

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Detalhes bibliográficos
Main Authors: Takada, Mamoru, Higuchi, Toru, Tozuka, Katsunori, Takei, Hiroyuki, Haruta, Masayuki, Watanabe, Junko, Kasai, Fumio, Inoue, Kenichi, Kurosumi, Masafumi, Miyazaki, Masaru, Sato-Otsubo, Aiko, Ogawa, Seishi, Kaneko, Yasuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663661/
https://ncbi.nlm.nih.gov/pubmed/23679233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-241
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