Transcriptional Regulation of Serine/Threonine Protein Kinase (AKT) Genes by Glioma-associated Oncogene Homolog 1

Aberrant activation of Hedgehog signaling has been described in a growing number of cancers, including malignant lymphomas. Here, we report that canonical Hedgehog signaling modulates the transcriptional expression of AKT genes and that AKT1 is a direct transcriptional target of GLI1. We identified...

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Autores principales: Agarwal, Nitin K., Qu, Changju, Kunkulla, Kranthi, Liu, Yadong, Vega, Francisco
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663557/
https://ncbi.nlm.nih.gov/pubmed/23580656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.425249
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